Innovative Drug Delivery Technologies
Terrain Pharma specializes in advanced drug delivery technologies that improve how therapies are absorbed, distributed, and experienced by patients. Our proprietary platforms address real-world clinical and formulation challenges through purposeful design and scalable manufacturing.
We’ve successfully commercialized products using each of these six core delivery systems, spanning transdermal, topical, and oral formats under our own labeler or through partners. Each platform has been pressure tested through real world use, offering a proven foundation for new product development and commercial scalability.
Drug-in-Adhesive Patch Technology
DIAmatrix™ DIA System
Streamlined Design. Sustained Delivery.
An adhesive patch made using solvent casting and consisting of only one layer, where the active ingredient is integrated directly into an acrylate matrix. DIAmatrix™ is optimized for systemic delivery over an extended period and supports APIs across pain, hormone, and behavioral health categories. Clean, efficient, and ready for manufacturing.
Applications:
- Transdermal pain management patches
- Hormone replacement therapy
- Smoking cessation systems
- CNS and behavioral health products
Clinical Advantages:
- Sustained 12–24 hour drug release
- Consistent drug plasma levels
- Streamlined production using optimized solvent systems
- Low-profile, skin-adherent design
Hydrogel Matrix Technologies
AdheraBase™ PAA Matrix
Simple. Breathable. Adaptable.
A minimalist hydrogel platform built from high molecular weight polyacrylic acid, glycerin, and water. Designed for comfort, flexibility, and rapid prototyping, AdheraBase™ delivers hydrophilic and low-molecular weight actives with exceptional skin adhesion and minimal formulation complexity. Ideal for non-occlusive patches, dermatology applications, and early stage product development.
Applications:
- Localized pain relief patches
- Dermatology actives and moisturizers
- Low-dose anti-inflammatory therapies
- Advanced wound care dressings
Clinical Advantages:
- High patient comfort and breathability
- Strong bioadhesion with minimal irritation
- Rapid customization for emerging therapies
- Supports hydrophilic and small-molecule actives
EnduraBase™ Advanced Hydrogel Matrix
Cohesive. Resilient. Clinic-Grade.
A structured hydrogel combining ultra high molecular weight sodium polyacrylate with PVP K90, kaolin, and stabilizers. EnduraBase™ is engineered for high viscosity, extended wear, and superior cohesion, making it ideal for physician dispensed patches, compound to commercial transitions, or demanding topical therapeutic environments.
Applications:
- Physician-applied pain or anti-inflammatory patches
- Topical adjuncts for orthopedic recovery
- Scalable from small-batch to large-scale production
- Dermatology and post-surgical support products
Clinical Advantages:
- Superior cohesion and wear resistance
- Moisture retention and pH stability
- High drug loading capacity
- Comfortable, skin-friendly profile
DermaLink™ Composite Matrix
Multiphase Architecture. Exceptional Wear Performance.
A high hydration, crosslinked hydrogel system built on sodium polyacrylate, polyacrylic acid, cellulose gum, and dual humectants. Reinforced with aluminum glycinate for form retention and integrated with surfactants for uniform API dispersion, DermaLink™ balances flexibility with mechanical strength. Ideal for complex, multi-active patches across musculoskeletal, neurology, and wound care markets.
Applications:
- Multi-active pain and inflammation patches
- Wound healing adjunct therapies
- Neurology-focused topical systems
- Long-wear musculoskeletal support patches
Clinical Advantages:
- Enhanced structural integrity and form stability
- Uniform dispersion of active agents
- Optimized for high-moisture retention
- Designed for extended wear comfort
Oral Solid Technologies
SymGel™ Softgel Technology
Precision-Filled. Patient-Preferred. Softgel Innovation.
SymGel™ is a gelatin based, liquid filled softgel platform engineered for enhanced oral delivery of lipid soluble APIs, surfactants, or solubilized actives. Manufactured using RP Scherer® rotary die encapsulation, it ensures consistent dose uniformity, oxidative protection, and a smooth, easy to swallow finish. Ideal for patients with swallowing challenges and for actives requiring improved bioavailability, SymGel™ supports high-throughput scalability and broad application across OTC, Rx, and nutraceutical markets.
Applications:
- Lipid-soluble drug delivery
- Vitamins and nutraceutical supplements
- Surfactant-based therapeutics
- Softgel line extensions for existing brands
Clinical Advantages:
- Improved bioavailability for poorly soluble drugs
- Enhanced patient adherence through easy swallowing
- Sealed softgel capsules for stability and protection
- Supports rapid or sustained-release profiles